Sphingosine-1-phosphate and renal vasoconstriction
نویسندگان
چکیده
منابع مشابه
Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature.
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, has been implicated in regulating vascular tone and participating in chronic and acute kidney injury. However, little is known about the role of S1P in the renal microcirculation. Here, we directly assessed the vasoresponsiveness of preglomerular and postglomerular microvascular segments to exogenous S1P using the in vitro bloo...
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Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of know...
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FOR MORE THAN A CENTURY FOLLOWING the discovery of sphingolipids, biochemists viewed these ubiquitous phospholipids as pharmacologically silent structural elements of the cell membrane. After the identification of G protein-coupled receptors for sphingosine-1-phosphate (S1P) (1, 8, 10), researchers began to recognize the importance of sphingolipid-mediated cell signaling, and this recognition l...
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ژورنال
عنوان ژورنال: Acta Physiologica
سال: 2017
ISSN: 1748-1708
DOI: 10.1111/apha.12971